13993-20-9Relevant academic research and scientific papers
Concise Synthesis of Spiro[indoline-3,2′-pyrrolidine] and 1-Azacarbazole Derivatives via Copper-Catalyzed Cyclization of Indoles
Wang, Peng-Fei,Chen, Chao,Chen, Hui,Han, Li-Shuai,Liu, Liu,Sun, Hongbin,Wen, Xiaoan,Xu, Qing-Long
, p. 2339 - 2344 (2017)
A high-yielding, copper-catalyzed dearomatization reaction of indole from 2-methylindole-derived oxime acetates was realized, providing access to structurally novel spiro[indoline-3,2′-pyrrolidine] derivatives in 67–98% yields. When the C-2 position of the indole was not substituted, azacarbazole derivatives were obtained in moderate yields. This transformation provides an efficient approach to access nitrogen-containing spiroindolenine and azacarbazole derivatives with wide substrate scope. (Figure presented.).
