13993-21-0Relevant academic research and scientific papers
Bismuth trichloride-catalyzed C-alkylation of pyrroles with electron-deficient olefins
Zhan, Zhuang-Ping,Yu, Jing-Liang,Yang, Wen-Zhen
, p. 1373 - 1382 (2006)
The BiCl3-catalyzed reaction of pyrroles with electron-deficient olefins generated the corresponding Michael adducts in high yields. Copyright Taylor & Francis Group, LLC.
Ruthenium-catalyzed functionalization of pyrroles and indoles with propargyl alcohols
Thies, Nora,Hrib, Cristian G.,Haak, Edgar
supporting information; experimental part, p. 6302 - 6308 (2012/06/18)
Several ruthenium-catalyzed atom-economic transformations of propargyl alcohols with pyrroles or indoles leading to alkylated, propargylated, or annulated heteroaromatics are reported. The mechanistically distinct reactions are catalyzed by a single ruthenium(0) complex containing a redox-coupled dienone ligand. The mode of activation regarding the propargyl alcohols determines the reaction pathway and depends on the alcohols' substitution pattern. Secondary substrates form alkenyl complexes by a 1,2-hydrogen shift, whereas the transformation of tertiary substrates involves allenylidene intermediates. 1-Vinyl propargyl alcohols are converted by a cascade allylation/cyclization sequence. The environmentally benign processes are of broad scope and allow the selective synthesis of highly functionalized pyrroles and indoles generating water as the only waste product. Copyright
Microwave-assisted addition of pyrroles to electron-deficient olefins: A rapid entry to C-alkyl pyrroles
Zhan, Zhuang-Ping,Yang, Wen-Zhen,Yang, Rui-Feng
, p. 2425 - 2428 (2007/10/03)
A general procedure for the Michael addition of pyrroles with electron-deficient olefins using silica gel supported reagent under microwave irradiation, has been developed. This new method is fast, efficient, environmentally benign and solvent-free. A cat
Addition of pyrroles to electron deficient olefins employing InCl3
Yadav,Abraham, Sunny,Subba Reddy,Sabitha
, p. 8063 - 8065 (2007/10/03)
Pyrroles undergo conjugate addition with electron deficient olefins in the presence of a catalytic amount of indium trichloride at ambient temperature to afford the corresponding Michael adducts in excellent yields with high selectivity without polymerisa
