139932-45-9Relevant academic research and scientific papers
Solid phase peptide synthesis: Fluoride ion release of protected peptide fragments
Ramage, Robert,Barron, Christine A.,Bielecki, Stanislaw,Holden, Robert,Thomas, David W.
, p. 499 - 514 (2007/10/02)
A linker unit for solid phase peptide synthesis has been designed on the basis of organosilicon chemistry which allows efficient release, by fluoride ion nucleophilic attack at Si, of t-butyl-derived protected peptide fragments. Such protected fragments w
SOLID PHASE PEPTIDE SYNTHESIS: FLUORIDE ION RELEASE OF PEPTIDE FROM THE RESIN
Ramage, R.,Barron, C. A.,Bielecki, S.,Thomas, D. W.
, p. 4105 - 4108 (2007/10/02)
A linkage to anchor the growing peptide chain has been designed in order to allow swift release of the peptide product by Bu4N(1+)*F(1-).Preparation of the linker (4) is described.
