1399347-26-2Relevant academic research and scientific papers
Hypervalent Iodine(III)-Mediated Cascade Cyclization of Propargylguanidines and Total Syntheses of Kealiinine B and C
Tian, Guilong,Fedoseev, Pavel,Van der Eycken, Erik V.
, p. 5224 - 5227 (2017/04/24)
An oxidative cascade cyclization of propargylguanidines promoted by phenyliodonium diacetate (PIDA) was developed. The protocol provides an efficient route for the synthesis of the alkaloids kealiinines B and C as well as homologues. The difference in the electronic nature of the acetylene substituent resulted in two ways of the cyclization. A plausible mechanism is proposed based on the experimental results.
Synthesis of the reported structures for kealiinines B and C
Gibbons, Joseph B.,Gligorich, Keith M.,Welm, Bryan E.,Looper, Ryan E.
supporting information, p. 4734 - 4737 (2013/01/15)
Syntheses of the reported structures of kealiinines B and C have been executed. An intermolecular electrophile-induced cyclization of a pendant arene on an ene-guanidine affords the tetracyclic, oxidized naphthimidazole cores.
