139935-23-2Relevant academic research and scientific papers
PHOSPHONIC SYSTEMS. 7. REACTIONS OF 2,3-EPOXYPHOSPHONATES WITH NUCLEOPHILES: PREPARATION OF 2,3-DISUBSTITUTED ALKYLPHOSPHONIC ESTERS AND RELATED SYSTEMS
Phillips, A. M. M. M.,Mphahlele, M. J.,Modro, A. M.,Modro, T. A.,Zwierzak, A.
, p. 165 - 174 (2007/10/02)
Diethyl 2,3-epoxyalkylphosphonates react regioselectively with various nucleophilic reagents yielding 2-hydroxy-3-substituted alkylphosphonic esters.The 2-hydroxy functionality can be easily converted into an ester or ether derivative.The reaction of diethyl 2,3-epoxypropylphosphonate with ketone enamines does not lead to hydroxyketophosphonates, but results in the corporation of the 3-phosphonopropylidene group (CH-CH2-PO3Et2) into the position 2 of the parent ketone.Key words: 2,3-Epoxyphosphonates; nucleophilic opening of epoxides; reaction of epoxides with enamines; 2-(3'-diethoxyphosphonyl)propylidenecycloalkanones.
