139937-37-4

Basic information

• Product Name: 4-BROMO-2-METHYLBENZENE-1-SULFONYL CHLORIDE
• Synonyms: BUTTPARK 98\57-56;4-BROMO-2-METHYLBENZENE-1-SULFONYL CHLORIDE;4-BROMO-2-METHYLBENZENESULFONYL CHLORIDE;4-BROMO-2-METHYLBENZENESULPHONYL CHLORIDE;2-Methyl-4-bromobenzenesulfonylchloride;4-Bromo-2-methylbenzenesulphonyl chloride 97%;5-Bromo-2-(chlorosulphonyl)toluene;4-Bromo-2-methylbenzenesulfonyl chloride 97%
• CAS NO: 139937-37-4
• Molecular Formula: C₇H₆BrClO₂S
• Molecular Weight: 269.54
• Product Categories: Phenyls & Phenyl-Het;Sulphonyl Chlorides;Phenyls & Phenyl-Het;Sulphonyl Chlorides
• Mol File: 139937-37-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 65-67°C
• Boiling Point: 164°C 15mm
• Flash Point: 139.4°C
• Appearance: /
• Density: 1.7g/cm³
• Vapor Pressure: 0.00135mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-BROMO-2-METHYLBENZENE-1-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-METHYLBENZENE-1-SULFONYL CHLORIDE(139937-37-4)
• EPA Substance Registry System: 4-BROMO-2-METHYLBENZENE-1-SULFONYL CHLORIDE(139937-37-4)

Safety Data

• Hazard Codes: Xi,Xn,C
• Statements: 34-29-14-22
• Safety Statements: 26-36/37/39-45-30-22-8
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: 8
• Hazardous Substances Data: 139937-37-4(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-methylbenzene-1-sulfonyl chloride is a chemical compound with the molecular formula C7H6BrClO2S. It is a sulfonating agent used in a variety of organic synthesis reactions, particularly in the production of pharmaceuticals and agrochemicals. 4-BROMO-2-METHYLBENZENE-1-SULFONYL CHLORIDE is an important intermediate in the synthesis of various sulfonyl compounds and is commonly used in the pharmaceutical industry. It is a colorless to pale yellow liquid with a sharp, choking odor and is highly reactive and toxic, requiring careful handling and storage.

InChI:InChI=1/C7H6BrClO2S/c1-5-4-6(8)2-3-7(5)12(9,10)11/h2-4H,1H3

Upstream product

• 583-75-5 4-Bromo-2-methylaniline 
• 14395-51-8 4-bromo-2-methythiophenol 
• 591-17-3 meta-bromotoluene 

Downstream Products

• 204129-75-9 (S)-2-(4-Bromo-2-methyl-benzenesulfonylamino)-3-(3-hydroxy-propylsulfanyl)-3-methyl-butyric acid methyl ester 
• 869663-64-9 4-bromo-2-methyl-N-(2-morpholin-4-yl-ethyl)benzene sulfonamide 
• 376349-91-6 4-Bromo-N-[4-(2-chloro-6-fluorophenyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide 
• 1244740-91-7 (2S)-4-[(4-bromo-2-methylphenyl)sulfonyl]-2-methyl-1-(phenylcarbonyl)piperazine 

Relevant articles and documents

NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS

The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

ETHYL N-BOC PIPERIDINYL PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Provided are compounds of Formula I as JAK inhibitors, which are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.