139937-75-0Relevant academic research and scientific papers
New enzymatic protecting group techniques for peptide and carbohydrate chemistry
Waldmann, H,Heuser, A,Braun, P,Kunz, H
, p. 799 - 802 (2007/10/02)
New methods are reported to establish enzymatic techniques for the chemo- and regioselective functionalization of carbohydrates, peptides and glycoconjugates.The N-terminal deprotection of peptides is achieved via hydrolysis of phenylacetamides, employing penicillin G acylase as biocatalyst.The C-terminal carboxyl function of peptides and O-glycopeptides is liberated by the lipase-mediated hydrolysis of heptyl esters.Penicillin G acylase and citrus acetylesterase are used to effect the chemo- and regioselective removal of phenylacetyl and acetyl blocking groups, respectively from differently protected carbohydrates.
