1399481-05-0

Upstream product

• 51-17-2 benzoimidazole 
• 4165-57-5 bromobenzene-d5 

Downstream Products

• 1399479-59-4 5,6-diphenylbenzo[4,5]imidazo[1,2-a]quinoline 
• 1399481-11-8 C₂₇H₁₄⁽²⁾H₄N₂ 
• 1399479-95-8 3-methoxy-5,6-diphenylbenzo[4,5]imidazo[1,2-a]quinoline 

Relevant academic research and scientific papers

Ni-Catalyzed Dual C-H Annulation of Benzimidazoles with Alkynes for Synthesis of π-Extended Heteroarenes

Transition metal catalyzed dual C-H activation and annulation with alkynes was an attractive protocol to construct polycyclic π-extended structures. However, most of them were dominated by noble metal catalysts. Disclosed herein was the study of base-metal Ni-catalysis for dual C-H annulation of N-aromatic imidazole, which produced a range of desired polycyclic aza-quinolines in 48-95% yields. The use of bifunctional phosphine oxide ligand proved to be critical for success.