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Relevant academic research and scientific papers

Multi-component reaction-functionalized chitosan complexed with copper nanoparticles: An efficient catalyst toward A3 coupling and click reactions in water

A novel bio-nanocomposite nanocatalyst with highly dispersed particles is synthesized through covalent functionalization of chitosan biopolymer by the multicomponent reaction (MCR) strategy. Surface functionalization of chitosan through MCR is led to the

Copper(II)-Schiff Base Complex-Functionalized Polyacrylonitrile Fiber as a Green Efficient Heterogeneous Catalyst for One-Pot Multicomponent Syntheses of 1,2,3-Triazoles and Propargylamines

A series of copper(II)-Schiff bases-functionalized polyacrylonitrile fiber catalysts were successfully prepared using copper acetate as copper source and characterized by elemental analysis, fourier-transfer infrared spectroscopy, ultraviolet-visible spectroscopy, X-ray photoelectron spectroscopy and inductively coupled plasma analysis. Excellent physical strength and thermal stability of the fiber catalysts were demonstrated by scanning electron microscopy, X-ray diffraction, thermogravimetric/differential scanning calorimetry analysis and mechanical strength measurements. Furthermore, these catalysts were successfully applied to one-pot multicomponent copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction and aldehyde, alkyne, amine (A3) coupling reaction in which the influences of different substituent groups on the catalytic activities of fiber catalysts were investigated in detail. Among them, the bis[N-ethyl-3,5-di-tert-butyl-salicylideneiminato]copper(II)-functionalized polyacrylonitrile fiber (PANS2F?Cu) as a green, efficient catalyst exhibited the best catalytic activity for its high hydrophobic micro-environment can aggregate the reactants to the catalytic sites and accelerate the reaction. In addition, the PANS2F?Cu has performed well in scaled-up experiment and shown excellent recyclability (at least ten times), and these enable it to have great potential for further applications. (Figure presented.).

Copper supported on MWCNT-guanidine acetic acid@Fe3O4: Synthesis, characterization and application as a novel multi-task nanocatalyst for preparation of triazoles and bis(indolyl)methanes in water

The synthesis of a new supported copper (Cu) nanocatalyst, with highly dispersed particles, based on magnetic guanidine acetic acid (GAA) functionalized multi-wall carbon nanotubes (MWCNT), Cu/MWCNT-GAA@Fe3O4, is reported. The synthe

Efficient synthesis and antibacterial activities of some novel 1,2,3-triazoles prepared from propargylic alcohols and benzyl azides

A simple and effective procedure for regioselective preparation of 1,2,3-triazoles from benzyl azides and propargylic alcohols is described using CuSO4·5H2O and sodium ascorbate. To screen the antibacterial activity of some newly synthesized triazole derivatives, minimum inhibitory concentration of 3d and 3k was evaluated against gram positive Staphylococcus aureus and Bacillus subtilis and gram negative Escherichia coli and Pseudomonas aeruginosa.

A copper acetate/2-aminobenzenthiol complex supported on magnetite/silica nanoparticles as a highly active and recyclable catalyst for 1,2,3-triazole synthesis

A novel and recoverable Cu(ii)/2-aminobenzenthiol complex immobilized on magnetite/silica nanoparticles (Fe3O4/SiO2 NPs) catalyzed the synthesis of 1,2,3-triazole derivatives via three-component condensation of terminal al

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

An abnormal N-heterocyclic carbene-copper(I) complex in click chemistry

Herein we report the synthesis of a copper(I) chloro complex using an abnormal N-heterocyclic carbene (aNHC) salt, 1,3-bis(2,6-diisopropylphenyl)-2,4- diphenylimidazolium. The Cu(aNHC) complex efficiently catalyzed Huisgen 1,3-dipolar cycloaddition reacti

Preparation of Cu(OAc)2/MCM-41 catalyst and its application in the one-pot synthesis of 1,2,3-triazoles in water

An efficient one-pot synthesis of 1,2,3-triazoles via the three-component coupling reaction between benzyl or alkyl bromides, terminal alkynes, and sodium azide in the presence of catalytic amounts of Cu(OAc)2/MCM-41 catalyst has been described