139962-96-2

Basic information

• Product Name: Benzene, 1-bromo-2-(diethoxymethyl)-4-(phenylmethoxy)-
• CAS NO: 139962-96-2
• Molecular Formula: C18H21BrO3
• Molecular Weight: 365.267
• Mol File: 139962-96-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-2-(diethoxymethyl)-4-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-2-(diethoxymethyl)-4-(phenylmethoxy)-(139962-96-2)
• EPA Substance Registry System: Benzene, 1-bromo-2-(diethoxymethyl)-4-(phenylmethoxy)-(139962-96-2)

Safety Data

• Hazardous Substances Data: 139962-96-2(Hazardous Substances Data)

Upstream product

• 2973-80-0 2-bromo-5-hydroxybenzaldehyde 
• 100-44-7 benzyl chloride 
• 85604-06-4 5-(benzyloxy)-2-bromobenzaldehyde 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 139962-97-3 3-Benzyloxy-6-boronobenzaldehyde diethyl acetal 
• 1187190-70-0 1,3-dihydro-1,5-dihydroxy-2,1-benzoxaborolane 

Relevant articles and documents

Preparation method for creboro intermediate

The invention discloses a preparation method for a creboro intermediate. The preparation method for the creboro intermediate comprises the following steps that 1, 2-bromo-5-hydroxybenzaldehyde reactswith benzyl chloride or benzyl bromide in an organic solvent (i) under the existence of alkali to obtain a compound shown in a formula II; 2, the compound shown in the formula II reacts with triethylorthoformate or trimethyl orthoformate or glycol in an organic solvent (ii) under the effect of an acid catalyst to obtain a compound shown in a formula III; 3, 2-methoxyl-4, 4, 5, 5-tetramethyl-1, 3,2-boron dioxane or 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-boron dioxane or trimethyl borate or triisopropyl borate reacts with a standby solution in an organic solvent (iii) under the condition thatthe reaction temperature is 10-30 DEG C, after the reaction is completed, hydrochloric acid is added for regulating the pH value to be not larger than 3, and after a quenching reaction is performed, acompound shown in a formula IV is obtained through the reaction under the temperature of 20-100 DEG C.

Total synthesis of plagiochins C, and D, macrocyclic bis(bibenzyl) constituents of plagiochila acantophylla

Plagiochins C (3) and D (4) were synthesized by convergent schemes. Rings C and B were joined by Ullman ether synthesis, the aryl-aryl bond between rings A and D was formed by Pd(0)-catalysed coupling of an arylboronic acid (ring D) and a bromobenzoic ester (ring A). Rings C and D were linked by the Wittig reaction, while final ring closure was effected by tetraphenylethene assisted Wurtz reaction.