139963-03-4

Upstream product

• 139963-02-3 (E)- and (Z)-1-<4-Benzyloxy-3-(4-methoxycarbonylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-methoxycarbonyl-4-methoxyphenyl)phenyl>-ethene 
• 139962-99-5 Methyl 2-(4-benzyloxy-2-formylphenyl)-5-methoxybenzoate 
• 139962-97-3 3-Benzyloxy-6-boronobenzaldehyde diethyl acetal 
• 35450-36-3 methyl 2-bromo-5-methoxybenzoate 

Downstream Products

• 139963-05-6 1-<2-Benzyloxy-4-(4-hydroxymethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-hydroxymethyl-4-methoxyphenyl)phenyl>-ethane 
• 139963-06-7 1-<2-Benzyloxy-4-(4-bromomethylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-bromomethyl-4-methoxyphenyl)phenyl>-ethane 
• 139963-04-5 1-<2-Benzyloxy-4-(4-methoxycarbonylphenoxy)phenyl>-2-<5-benzyloxy-2-(2-methoxycarbonyl-4-methoxyphenyl)phenyl>-ethane 

Relevant academic research and scientific papers

Total synthesis of plagiochins C, and D, macrocyclic bis(bibenzyl) constituents of plagiochila acantophylla

Plagiochins C (3) and D (4) were synthesized by convergent schemes. Rings C and B were joined by Ullman ether synthesis, the aryl-aryl bond between rings A and D was formed by Pd(0)-catalysed coupling of an arylboronic acid (ring D) and a bromobenzoic ester (ring A). Rings C and D were linked by the Wittig reaction, while final ring closure was effected by tetraphenylethene assisted Wurtz reaction.