139964-03-7Relevant academic research and scientific papers
A SIMPLE ROUTE TO 2-METHYL-2-CYCLOPENTENONES
Vasilevskii, D. A.,Sviridov, S. V.,Kulinkovich, O. G.
, p. 1885 - 1887 (2007/10/02)
Reaction of carboxylate esters with ethylmagnesium bromide in the presence of tetraisopropoxytitanium has given 1-(3-oxobutyl)cyclopropanol, 1-cyclopropanol, and bis-1,2-(1-hydroxy-1-cyclopropyl)ethane.Treatment of these compounds with sodium hydroxide in aqueous ethanol affords 81-83 percent yields of the 3-substituted-2-methyl-2-cyclopentenones by cleavage of the three-carbon ring followed by cyclization of the intermediate ethyl ketones.
