1399654-82-0Relevant academic research and scientific papers
THIENODIAZEPINE DERIVATIVES AND APPLICATION THEREOF
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Paragraph 0133; 0136-0137, (2020/08/09)
The present invention relates to a class of thienodiazepine derivatives and an application thereof in the preparation of a drug for the treatment of diseases associated with bromodomain and extra-terminal (BET) Bromodomain inhibitors. Specifically, the present invention relates to compounds represented by formulas (I) and (II), as well as pharmaceutically acceptable salts thereof.
A convenient cyclopropanation process of oxindoles via bromoethylsulfonium salt
Qin, Hui,Miao, Yuanyuan,Zhang, Ke,Xu, Jian,Sun, Haopeng,Liu, Wenyuan,Feng, Feng,Qu, Wei
, p. 6809 - 6814 (2018/10/20)
A practical convenient conversion of oxindoles into the corresponding spirocyclopropyl oxindoles is achieved efficiently using bromoethylsulfonium salt, which is easily prepared on a large scale and is stable crystalline. This reaction of bromoethylsulfonium salt with different substituted unprotected oxindoles proceeded under mild condition and provided moderate yields.
Zinc triflate-mediated cyclopropanation of oxindoles with vinyl diphenyl sulfonium triflate: a mild reaction with broad functional group compatibility
Zhou, Mingwei,En, Ke,Hu, Yimin,Xu, Yufang,Shen, Hong C.,Qian, Xuhong
, p. 3741 - 3745 (2017/02/05)
The first use of zinc triflate for the cyclopropanation of unprotected oxindoles with vinyl diphenyl sulfonium triflate salt is reported. The reaction proceeded under ambient conditions and consistently provided high yields with broad functional group tolerability. The utility for the late-stage functionalization (LSF) of complex molecules is demonstrated.
