1399710-01-0Relevant academic research and scientific papers
Design, synthesis and molecular docking studies of sinomenine derivatives
Chai, Xiaoyun,Guan, Zhongjun,Yu, Shichong,Zhao, Qingjie,Hu, Honggang,Zou, Yan,Tao, Xia,Wu, Qiuye
, p. 5849 - 5852 (2012/11/07)
In order to search for drugs with excellent anti-inflammatory activities, a series of novel sinomenine derivatives were designed, synthesized, and evaluated for their inhibition activities against NF-κB activation induced by lipopolysaccharide (LPS). Compared with the natural parent sinomenine, compounds 2a-w showed higher activity, while compounds 1a-o showed similar activity against NF-κB. Moreover, a molecular model for the binding between compound 2v and the active site of p50 was provided on the basis of the computational docking results.
