139979-35-4Relevant articles and documents
SYNTHESIS OF 1,4-BENZODIAZEPINES AND QUINAZOLINES BASED ON CROWNED o-AMINO KETONES
Ivanov, E.I.,Polishchuk, A.A.,Ivanova, R.Yu.
, p. 1337 - 1339 (2007/10/02)
Cyclization of the o-amino ketone derivatives of dibenzo-18-crown-6 ether gave the corresponding crown-annelated 1,4-benzodiazepines and quinazolines. 1,4-Benzodiazepines containing the macrocyclic ring were obtained from the initial o-amino ketones and the acid chloride of glycine hydrochloride or bromoacetyl bromide followed by treatment with ammonia.A convenient method for the synthesis of the quinazolines is cyclization of the o-amino ketones in formamide.