1399845-85-2Relevant academic research and scientific papers
Novel aminoalcohol derivatives bearing 4-phenylphenol as antischistosomal drugs
Duan, Li-Ping,Xue, Jian,Tao, Yi,Zhang, Hao-Bing
, p. 694 - 697 (2012/09/22)
There is a need to develop new antischistosomal compounds when the only available therapeutic agents praziquantel large-scale used in the world. A series of novel aminoalcohol derivatives bearing 4-phenylphenol moiety were designed and synthesized. The structures of all the newly synthesized compounds were identified by elemental analysis, 1H-NMR, 13C-NMR and LC-MS. Their biological activities were evaluated against Schistosoma japonicum in mice by an oral route. Among these compounds, in vivo, at concentrations 400mg/kg of mouse, compound 1-(biphenyl-4′-yloxy)-3-(1′-(3′, 4′-difluorophenyl)ethylamino)propan-2-ol (3j) produced the highest activity with 93.0% deparasitization. These compounds may find usefulness in the discovery and development of new antischistosomal drugs.
