DBCO-sulfo-SE, also known as Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester, is a water-soluble sulfo-NHS ester reagent containing a DBCO (Dibenzocyclooctyne) moiety. It is designed for the simple and efficient labeling of antibodies, proteins, and other primary amine-bearing macromolecules with the DBCO moiety in 100% aqueous buffers. DBCO is widely utilized in copper-free Click Chemistry reactions, making DBCO-sulfo-SE a versatile tool in various applications.
1400191-52-7
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Basic information
- Product Name: DBCO-sulfo-SE
- Synonyms: DBCO-sulfo-NHS ester;DBCO-sulfo-SE;Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester
- CAS NO:1400191-52-7
- Molecular Formula: C25H21N2NaO8S
- Molecular Weight: 532.49761
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1400191-52-7.mol
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Chemical Properties
- Melting Point: 240-260 °C
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -20°C
- Solubility: N/A
- CAS DataBase Reference: DBCO-sulfo-SE(CAS DataBase Reference)
- NIST Chemistry Reference: DBCO-sulfo-SE(1400191-52-7)
- EPA Substance Registry System: DBCO-sulfo-SE(1400191-52-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1400191-52-7(Hazardous Substances Data)
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1400191-52-7 Usage
Uses
Used in Bioconjugation:DBCO-sulfo-SE is used as a bioconjugation agent for the covalent modification of primary amine-bearing macromolecules, such as antibodies and proteins, to introduce the DBCO moiety. This modification enables the subsequent use of Click Chemistry reactions for the attachment of various probes, drugs, or other biomolecules.
Used in Targeted Drug Release Systems:
In the pharmaceutical industry, DBCO-sulfo-SE is used as a key component in the synthesis of stimuli-responsive DNA-gated nano-sized metal-organic frameworks (NMOFs). These NMOFs can act as carriers for a fluorescent agent or anticancer drug, making them highly useful in targeted drug release systems. The covalent modification of NMOFs with nucleic acids via click chemistry allows for the development of smart drug delivery systems that can release their payload in response to specific biological triggers.
Used in Diagnostics and Imaging:
DBCO-sulfo-SE can be employed as a labeling agent for the development of diagnostic tools and imaging agents. By attaching the DBCO moiety to biomolecules, researchers can utilize Click Chemistry to introduce fluorescent tags, radioactive isotopes, or other imaging agents for various imaging modalities, such as fluorescence microscopy, positron emission tomography (PET), or magnetic resonance imaging (MRI).
Used in Research and Development:
In the field of life sciences research, DBCO-sulfo-SE is used as a valuable tool for the study of protein-protein interactions, cellular signaling pathways, and other biological processes. The ability to site-specifically label proteins and other macromolecules with the DBCO moiety allows researchers to investigate the function and dynamics of these molecules in a more controlled and precise manner.
Check Digit Verification of cas no
The CAS Registry Mumber 1400191-52-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,0,1,9 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.Calculate Digit Verification of CAS Registry Number 1400191-52:
(9*1)+(8*4)+(7*0)+(6*0)+(5*1)+(4*9)+(3*1)+(2*5)+(1*2)=97
97 % 10 = 7
So 1400191-52-7 is a valid CAS Registry Number.
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1400191-52-7Downstream Products
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DBCO-sulfo-SE
