14003-22-6Relevant academic research and scientific papers
Lipase-catalyzed highly diastereoselective direct vinylogous Michael addition reaction of α,α-dicyanoolefins to nitroalkenes
Zhou, Long-Hua,Wang, Na,Chen, Guan-Nan,Yang, Qi,Yang, Sheng-Yong,Zhang, Wei,Zhang, Yang,Yu, Xiao-Qi
, p. 170 - 177 (2014)
Lipase-catalyzed direct vinylogous Michael addition reactions of electron-deficient vinyl malononitriles to nitroalkenes are reported for the first time. A series of nitroalkenes reacting with vinyl malononitriles generate the corresponding products with
Synthesis of Novel Pterocarpen Analogues via [3?+?2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines
Chen, Hui,Zhao, Sihan,Cheng, Shaobing,Dai, Xingjie,Xu, Xiaoying,Yuan, Weicheng,Zhang, Xiaomei
, p. 1672 - 1683 (2019/04/08)
By employing triethylamine as a catalyst, [3?+?2] coupling-elimination cascade of α,α-dicyanoolefins with quinone monoimines was realized. The reactions afforded various novel pterocarpen analogues with generally moderate yields (up to 75%). In addition, a plausible reaction mechanism was proposed.
Organocatalyzed asymmetric 1,6-conjugate addition of para-quinone methides with dicyanoolefins
Li, Xuanyi,Xu, Xiuyan,Wei, Weiwei,Lin, Aijun,Yao, Hequan
supporting information, p. 428 - 431 (2016/02/19)
A chiral thiourea catalyzed asymmetric 1,6-conjugate addition of para-quinone methides with dicyanoolefins has been developed. The reaction provided an efficient approach to the synthesis of chiral diarylmethine skeletons in good yields (up to 99% yield) with high diastereo- and enantioselectivity (>20:1 dr and up to 99.5:0.5 er), also on a gram scale. The preliminary mechanistic study showed that the remote stereocontrol was achieved through intermolecular hydrogen-bond interaction between the chiral thiourea catalyst and the para-quinone methides directly for the first time.
Organocatalytic asymmetric allylic carbon-carbon bond formation
Poulsen, Thomas B.,Bell, Mark,Jrgensen, Karl Anker
, p. 63 - 70 (2007/10/03)
Organocatalytic allylic C-C bond-forming addition of activated alkylidenes to alkyl and aryl nitroalkenes has been achieved with high diastereo- and enantioselectivity. Chiral tertiary amine catalysts are used to give allyl intermediates which exhibit γ-s
