14003-35-1Relevant academic research and scientific papers
Quinoxalinone compounds useful for expanding the lumina or air passages in mammals
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, (2008/06/13)
Compounds of the formula below are useful for expanding the lumina or air passages in a mammal in need of said treatment. The compounds are also useful for treating atopic eczema and urticaria. STR1 wherein X and Y are the same or different and are hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, alkyl of one to four carbon atoms, inclusive, alkoxy of one to four carbon atoms, inclusive, and cyano; R1 is hydrogen, methyl or ethyl; R2 is hydrogen, alkyl of one to six carbon atoms, inclusive, phenyl, benzyl, CH2 Z wherein Z is fluoro, chloro, or bromo, CO2 M, CH2 CO2 M, CH2 CH2 CO2 M and CHR3 CO2 M wherein M is hydrogen, alkyl of one to four carbon atoms, inclusive, or a physiologically acceptable metal or amine cation and R3 is alkyl of one to three carbon atoms, inclusive, with the proviso that M is not hydrogen when R2 is CH2 CO2 M or a CHR3 CO2 M.
Reactions of o-phenylenediamine and some iminophosphorane derivatives with dimethyl acetylenedicarboxylate
Briggs, Elizabeth M.,Brown, Geoffrey W.,Dawson, William T.,Jiricny, Josef
, p. 641 - 642 (2007/10/06)
Reactions of certain iminotriphenylphosphoranes derived from o-phenylenediamine with dimethyl acetylenedicarboxylate (DMA) involve Wittig-like elimination of triphenylphosphine oxide from an ester carbonyl group; o-phenylenediamine reacts with DMA in ether to give a mixture of tautomers.
