1400301-84-9Relevant academic research and scientific papers
Highly enantioselective conjugate addition of nitroalkanes to enones catalyzed by cinchona alkaloid derived primary amine
Liu, Wenjing,Mei, Desheng,Wang, Wei,Duan, Wenhu
supporting information, p. 3791 - 3793 (2013/07/05)
A cinchona alkaloid derived primary amine catalyzed conjugate addition of nitroalkanes to enones is described. The process affords the Michael adducts in good yield and with up to 99% ee for both acyclic and cyclic enones.
Camphor-derived C1-symmetric chiral diamine organocatalysts for asymmetric Michael addition of nitroalkanes to enones
Zhou, Yirong,Liu, Qiang,Gong, Yuefa
, p. 7618 - 7627 (2012/10/29)
A series of stable C1-symmetric chiral diamines (2a-2l) were conveniently synthesized by condensing exo-(-)-bornylamine or (+)-(1S,2S,5R)-menthylamine with various commercially available Cbz-protected amino acids. Among them, 2a can efficiently promote the Michael addition of nitroalkanes to a broad scope of enones with high yields (up to 96%) and excellent enantioselectivities (up to 98%) under mild conditions.
