1400301-87-2Relevant academic research and scientific papers
Camphor-derived C1-symmetric chiral diamine organocatalysts for asymmetric Michael addition of nitroalkanes to enones
Zhou, Yirong,Liu, Qiang,Gong, Yuefa
, p. 7618 - 7627 (2012/10/29)
A series of stable C1-symmetric chiral diamines (2a-2l) were conveniently synthesized by condensing exo-(-)-bornylamine or (+)-(1S,2S,5R)-menthylamine with various commercially available Cbz-protected amino acids. Among them, 2a can efficiently promote the Michael addition of nitroalkanes to a broad scope of enones with high yields (up to 96%) and excellent enantioselectivities (up to 98%) under mild conditions.
