1400575-42-9

Upstream product

• 1322091-22-4 C₁₆H₁₁FO 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 1383274-43-8 N-(((4-bromo-6-fluoro-3-p-tolylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Generation of diverse 1-(isoquinolin-1-yl)guanidines via a sequential multi-component/cross-coupling reaction

A multi-component reaction of 2-alkynylbenzaldehyde, 4- methylbenzenesulfonohydrazide, carbodiimide, and bromine is reported, which generates 1-(4-bromoisoquinolin-1-yl)guanidines in good yields under mild conditions. The products could be further elaborated via a palladium-catalyzed Suzuki-Miyaura coupling reaction, leading to the diverse 1-(isoquinolin-1-yl) guanidines.