1400742-66-6Relevant articles and documents
Synthetic method of 2-substituted-1-(2-thiophene)-1-pentanone
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Paragraph 0014; 0015, (2018/03/28)
The invention discloses a synthetic method of 2-substituted-1-(2-thiophene)-1-pentanone. The method includes the steps: taking n-pentanoic acid and bromine as raw materials, and taking phosphorus trichloride as a catalyst to prepare 2-bromovaleric acid; mixing the 2-bromovaleric acid and thionyl chloride to obtain 2-bromovaleryl chloride; taking aluminum trichloride as a catalyst, dropping thiophene into 2-bromovaleryl chloride, and stirring mixture to obtain 2-bromine-1-(2-thiophene)-1-pentanon; performing heating reflux on the 2-bromine-1-(2-thiophene)-1-pentanon and pyrrolidine or piperidine to obtain the 2-substitution-1-(2-thiophene)-1-pentanone. A target compound is a precursor compound for synthesizing drugs such as anticonvulsant drugs or vasodilator drugs and provided with an important pharmaceutical intermediate.