1400767-16-9

Basic information

• Product Name: C₃₂H₂₄N₂O₅S
• Synonyms: C₃₂H₂₄N₂O₅S
• CAS NO: 1400767-16-9
• Molecular Weight: 548.619
• Mol File: 1400767-16-9.mol

Chemical Properties

• CAS DataBase Reference: C₃₂H₂₄N₂O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₂H₂₄N₂O₅S(1400767-16-9)
• EPA Substance Registry System: C₃₂H₂₄N₂O₅S(1400767-16-9)

Safety Data

• Hazardous Substances Data: 1400767-16-9(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 144459-98-3 5-methylcarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidin-2(1H)-thione 
• 106-96-7 propargyl bromide 

Relevant articles and documents

One pot efficient diversity oriented synthesis of polyfunctional styryl thiazolopyrimidines and their bio-evaluation as antimalarial and anti-HIV agents

An efficient one pot synthesis of a series of pluripotent (E)-1-(3-methyl-5-aryl-7-styryl-5H-thiazolo[3,2-a]pyrimidin-6-yl) -3-arylprop-2-en-1-ones is reported. It involves reaction of 5-acetyl-6-methyl-4-aryl-dihydropyrimidine-2-thiones, propargyl bromide and aromatic aldehydes in presence of ethanolic KOH. The newly synthesized compounds were evaluated for antimalarial activity against Plasmodium falciparum and as HIV-RT inhibitors. Most of the compound displayed potent antimalarial activity with IC50 2 μg/mL. Compounds 6, 11 and 20 showed better activity against P. falciparum K1 strains in comparison to standard drug chloroquine. Compounds 6, 11, and 16 exhibited 73.44, 66.92, and 70.81% HIV-RT inhibition at 100 μg/mL.