1400767-43-2Relevant academic research and scientific papers
Stereoselective synthesis of pseudoglycosides catalyzed by TeCl4 under mild conditions
Freitas, Juliano C.R.,Couto, Túlio R.,Paulino, Ant?nio A.S.,De Freitas Filho, Jo?o R.,Malvestiti, Ivani,Oliveira, Roberta A.,Menezes, Paulo H.
, p. 8645 - 8654 (2012/10/29)
Catalytic amounts of tellurium(IV) tetrachloride were used to promote the O-glycosylation of 3,4,6-tri-O-acetyl-d-glucal to give the corresponding 2,3-unsaturated-O-glycosides. With simple alcohols, the desired compounds were obtained in good yields and excellent anomeric selectivity in a short reaction time using only 2 mol % of the catalyst. The application of the method in the synthesis of a small set of glycopyranosides with rigid or flexible linkers gave the corresponding α anomers as products in good yields. Further applications of some of the synthesized compounds in allylation reaction of aldehydes gave the corresponding homoallylic alcohols in good yields.
