1400807-68-2

Upstream product

• 1400807-67-1 2,4-bis(allyloxy)-5-iodobenzaldehyde 
• 95-01-2 2,4-Dihydroxybenzaldehyde 

Relevant academic research and scientific papers

Asymmetric total synthesis of smyrindiol employing an organocatalytic aldol key step

The first organocatalytic asymmetric synthesis of smyrindiol, by using an (S)-proline catalyzed enantioselective intramolecular aldol reaction as the key step, is described. Smyrindiol was synthesized from commercially available 2,4-dihydroxybenzaldehyde in 15 steps, with excellent stereoselectivity (de = 99%, ee = 99%). In the course of this total synthesis a new and mild coumarin assembly was developed.