1400808-08-3

Upstream product

• 79200-56-9 (-)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1400808-09-4 (1R,4R)-benzyl 5-oxo-2-azabicyclo [2.2.1]heptanes-2-carboxylate 
• 1400808-10-7 (1R,4R,5R)-benzyl 5-(4-methoxyphenylamino)-2-azabicyclo[2.2.1]heptanes-2-carboxylate 
• 1400808-11-8 (1R,4R,5R)-benzyl 5-(tert-butoxycarbonyl(4-methoxyphenyl)amino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 1400808-12-9 (1R,4R,5R)-benzyl 5-(tert-butoxycarbonylamino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 

Relevant academic research and scientific papers

HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC MUTAGENIC AND FIBROTIC CONDITIONS AND DISORDERS

The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L1, A, X1

HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS

The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): (I), wherein L1, A, X1, X2, R1, R2, and R3 are described herein.

TRICYCLIC GYRASE INHIBITORS FOR USE AS ANTIBACTERIAL AGENTS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

TRICYCLIC GYRASE INHIBITORS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.