1400867-48-2

Basic information

• Product Name: HT-2 Toxin 4-Glucuronide
• Synonyms: HT-2 Toxin 4-Glucuronide
• CAS NO: 1400867-48-2
• Molecular Formula: C₂₈H₄₀O₁₄
• Molecular Weight: 600.6088
• Product Categories: Heterocycles, Mutagenesis Research Chemicals, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1400867-48-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: HT-2 Toxin 4-Glucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: HT-2 Toxin 4-Glucuronide(1400867-48-2)
• EPA Substance Registry System: HT-2 Toxin 4-Glucuronide(1400867-48-2)

Safety Data

• Hazardous Substances Data: 1400867-48-2(Hazardous Substances Data)

Usage

Uses

HT-2 Toxin 4-Glucuronide is an analogue of HT-2 Toxin (H671800) which is a trichothecene group mycotoxin. HT-2 Toxin is the 4-hydroxy analogue of T-2 Toxin (T002980) which has been shown to induce DNA damage and cell death on prolonged administration.

Upstream product

• 21259-20-1 T-2 toxin 
• 1245697-26-0 UDP-glucuronic acid 

Downstream Products

• 489-91-8 D-glucuronic acid 
• 26934-87-2 HT-2 toxin 

Relevant articles and documents

HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: Enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes

Glucuronides of the mycotoxin T-2 toxin and its phase I metabolite HT-2 toxin are important phase II metabolites under in vivo and in vitro conditions. Since standard substances are essential for the direct quantitation of these glucuronides, a method for the enzymatic synthesis of T-2 and HT-2 toxin glucuronides employing liver microsomes was optimized. Structure elucidation by nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry revealed that besides T-2 toxin glucuronide and HT-2 toxin 3-glucuronide also the newly identified isomer HT-2 toxin 4-glucuronide was formed. Glucuronidation of T-2 and HT-2 toxin in liver microsomes of rat, mouse, pig, and human was compared and metabolites were analyzed directly by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). A distinct, species specific pattern of glucuronidation of T-2 and HT-2 toxin was observed with interesting interindividual differences. Until recently, glucuronides have frequently been analyzed indirectly by quantitation of the aglycone after enzymatic cleavage of the glucuronides by β-glucuronidase. Therefore, the hydrolysis efficiencies of T-2 and HT-2 toxin glucuronides using β-glucuronidases from Helix pomatia, bovine liver, and Escherichia coli were compared.