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Drotaverin hydrochloride, also known as Drotaverine, is a synthetic isoquinoline derivative that functions as a spasmolytic and analgesic agent. It operates by inhibiting the phosphodiesterase enzyme, which results in elevated levels of cyclic adenosine monophosphate (cAMP) in smooth muscle cells. This action leads to the relaxation of smooth muscles in blood vessels and the gastrointestinal tract, causing vasodilation and a reduction in muscle contractions.

14009-24-6

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14009-24-6 Usage

Uses

Used in Pharmaceutical Industry:
Drotaverin hydrochloride is used as a therapeutic agent for the treatment of smooth muscle spasm-related conditions due to its ability to induce muscle relaxation and alleviate pain.
Used in Gastrointestinal Applications:
Drotaverin hydrochloride is used as an antispasmodic agent for conditions such as irritable bowel syndrome, where it helps to reduce spasms and associated pain by relaxing the smooth muscles of the gastrointestinal tract.
Used in Obstetric and Biliary Applications:
Drotaverin hydrochloride is used as a pain reliever and muscle relaxant in conditions like uterine and biliary colic, providing relief from spasms and discomfort caused by muscle contractions in these areas.
Used in Smooth Muscle Disorder Treatments:
Drotaverin hydrochloride is used as a treatment for various smooth muscle disorders, where its spasmolytic and analgesic properties contribute to improved patient comfort and reduced symptoms. Its well-tolerated nature and good safety profile make it a widely accepted choice for such treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 14009-24-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,0 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14009-24:
(7*1)+(6*4)+(5*0)+(4*0)+(3*9)+(2*2)+(1*4)=66
66 % 10 = 6
So 14009-24-6 is a valid CAS Registry Number.
InChI:InChI=1/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;

14009-24-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline

1.2 Other means of identification

Product number -
Other names Drotaverina [INN-Spanish]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14009-24-6 SDS

14009-24-6Upstream product

14009-24-6Relevant academic research and scientific papers

Synthesis of 14C labelled drotaverinum hydrochloride

Koltai,Banfi,Engler,et al.

, p. 351 - 354,352,353 (2007/10/05)

Drotaverinum hydrochloride was labelled with 14C isotope in position 1 of the isoquinoline ring. A rapid synthesis with high radiochemical yield was elaborated.

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