1400900-06-2Relevant academic research and scientific papers
Synthesis of 1,5-benzothiazepines: Part-38-synthesis and antimicrobial evaluation of bicyclic 8-substituted-2,5-dihydro-2 4 diaryl-1,5-benzothiazepines and tetracyclic 10-substituted-6 7-diaryl 6a,7-dihydro-6h[1] benzopyrano [3,4-c] [1,5] benzodiazepines
Pant, Seema,Sharma, Priyanka,Jadon, Rajkumari
, p. 341 - 348 (2013/09/24)
The reactions of the propenone, 1-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)- 2-propenone and the arylidene flavanone, 3-(3,4-dimethoxybenzylidene)-2'- chloroflavanone have been carried out with 5-substituted-2-aminobenzenethiols, the substituents being fluoro, chloro or bromo, methyl and methoxy or ethoxy to give respective 12 new compounds, 8-substituted-2,5-dihydro-4-(4-chlorophenyl)- 2-(3,4-dimethoxyphenyl)-1,5-benzothiazepines and 10-substituted-6-(2- chlorophenyl)-6a, 7-dihydro-7-(3,4-dimethoxyphenyl)-6H [1] benzopyrano [3,4-c] [1,5] benzodiazepines, in acidic medium, in 55-67% yields. The final products were characterized on the basis of analytical and spectral data. The synthesized biyclic and tetracyclic compounds were compared for their relative antimicrobial activity against the bacteria, Staphylococcus aureus and Pseudomonas aeruginosa and the fungus, Candida albicans. Most of the compounds showed good antifungal activity (compared to fluconazole) against Candida albicans.
