1400901-84-9Relevant academic research and scientific papers
Synthesis, characterization and cytotoxic effect of some new thiazolyl hydrazone derivatives of 1-indanone
Nazim, Urooj,Narayanan, Silpa,Ali, Mohsin,Khan, Khalid Mohammed,Ali, Basharat,Li, Jonathan,Chen, Zhe-Sheng,Ahmed, Mansoor,Yang, Dong-Hua
, p. 244 - 252 (2021/05/19)
In the present study, a series of twelve thiazolyl hydrazone derivatives of 1-indanone was synthesized and characterized by various spectroscopic techniques such as UV-Visible, NMR, IR and Mass Spectrometry. All the synthesized target compounds were subjected to MTT assay for cytotoxicity screening and evaluation of their anti-cancer activity on various cell lines of human cancer including glioblastoma (SNB-19), prostate cancer (PC-3), Lung cancer (NCI-H460), human ovarian carcinoma (SK-OV-3 and IGROV-1), human leukemia (K-562) and human colon cancer(HCT116).Three synthesized compounds showed promising anti-cancer activity against the colon cancer cell HCT 116 cells with IC50 ranging from 1.25±0.02 to 5.04±0.2 μM. On the other hand all the compounds didn't show cytotoxic activity against other forms of human cancer cells.
Synthesis and biological evaluation of some novel 1-indanone thiazolylhydrazone derivatives as anti-Trypanosoma cruzi agents
Caputto, Maria E.,Moglioni, Albertina G.,Finkielsztein, Liliana M.,Ciccarelli, Alejandra,Lombardo, Elisa,Frank, Fernanda,Moltrasio, Graciela Y.,Vega, Daniel
, p. 155 - 163,9 (2020/07/31)
A series of novel 4-arylthiazolylhydrazones (TZHs) derived from 1-indanones were synthesized in good yields (66-92%) in a simple procedure using microwave irradiation and then characterized by spectroscopy studies. The compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against the epimastigote, trypomastigote and amastigote forms of the parasite. Most TZHs displayed excellent activity, and were more potent and selective than the reference drug Benznidazole, used in the current chemotherapy. Analysis of the free sterols from parasite incubated with the compounds showed that inhibition of ergosterol biosynthesis is a possible target for the action of these new TZHs. In particular, TZH 9 emerged as a promising antichagasic compound to be evaluated in animal models.
