1400907-11-0Relevant academic research and scientific papers
Scissoring Enaminone C=C Double Bond by Free Radical Process for the Synthesis of α-Trifluoromethyl Ketones with CF3SO2Na
Gan, Lu,Yu, Qing,Liu, Yunyun,Wan, Jie-Ping
, p. 1231 - 1237 (2020/12/21)
The C=C double bond cleavage on tertiary enaminones, enabling the formation of a new C-CF3 bond, has been realized as a practical method for the synthesis of α-trifluoromethyl ketones with only the promotion of TBHP and ambient heating. Control experiments support that the reactions proceed via a featured free radical process. The deuterium labeling experiment employing D2O indicates that water participated in the product formation by donating the hydrogen atom for the newly generated α-C-H bond in the product.
Trifluoromethylation of α-haloketones
Novak, Petr,Lishchynskyi, Anton,Grushin, Vladimir V.
supporting information, p. 16167 - 16170 (2012/11/07)
The C-X bond (X = Br, Cl) of α-haloketones is smoothly trifluoromethylated with the fluoroform-derived CuCF3 reagent recently developed in our laboratories. This is the first nucleophilic α-trifluoromethylation reaction of carbonyl compounds and a rare example of CF3-C(sp3) coupling. The transformation employs only low-cost chemicals and cleanly occurs in up to 99% yield at room temperature, thereby providing an unprecedentedly easy entry to valuable 2,2,2- trifluoroethylketones.
