1400907-15-4Relevant academic research and scientific papers
Trifluoromethylation of α-haloketones
Novak, Petr,Lishchynskyi, Anton,Grushin, Vladimir V.
, p. 16167 - 16170 (2012)
The C-X bond (X = Br, Cl) of α-haloketones is smoothly trifluoromethylated with the fluoroform-derived CuCF3 reagent recently developed in our laboratories. This is the first nucleophilic α-trifluoromethylation reaction of carbonyl compounds and a rare example of CF3-C(sp3) coupling. The transformation employs only low-cost chemicals and cleanly occurs in up to 99% yield at room temperature, thereby providing an unprecedentedly easy entry to valuable 2,2,2- trifluoroethylketones.
