1400941-66-3

Basic information

• Product Name: C₂₂H₂₁FN₂O
• CAS NO: 1400941-66-3
• Molecular Weight: 348.42
• Mol File: 1400941-66-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₁FN₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₁FN₂O(1400941-66-3)
• EPA Substance Registry System: C₂₂H₂₁FN₂O(1400941-66-3)

Safety Data

• Hazardous Substances Data: 1400941-66-3(Hazardous Substances Data)

Upstream product

• 6120-95-2 1-phenyl-1-cyclopropane carboxylic acid 
• 198474-06-5 5-fluoro-3-pyrrolidin-3-yl-1H-indole 
• 1400941-74-3 C₁₂H₈FN₃ 
• 773081-10-0 C₁₄H₁₁FN₂O₂ 
• 2338-71-8 5-fluoro-1H-indole-3-carbaldehyde 

Relevant articles and documents

Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type i

Indole-pyrrolidines were identified as inhibitors of 11β- hydroxysteroid dehydrogenase type 1 (11β-HSD1) by high-throughput screening. Optimisation of the initial hit through structure-based design led to 7-azaindole-derivatives, with the best analogues displaying single digit nanomolar IC50 potency. The modeling hypotheses were confirmed by solving the X-ray co-crystal structure of one of the lead compounds. These compounds were selective against 11β-hydroxysteroid dehydrogenase type 2 (selectivity ratio >200) and exhibited good inhibition of 11β-HSD1 (IC50 a cellular model (3T3L1 adipocytes).