1400997-76-3

Usage

Uses

Used in Pharmaceutical Synthesis:
(RS)-2-(4-bromo-2-fluorophenyl)oxirane is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of chiral building blocks, which are essential for the development of enantiomerically pure drugs with improved efficacy and reduced side effects.
Used in Agrochemical Production:
In the agrochemical industry, (RS)-2-(4-bromo-2-fluorophenyl)oxirane is utilized as a starting material for the production of various agrochemicals. Its reactivity and structural properties make it a valuable component in the formulation of pesticides and other agricultural products designed to protect crops and enhance yield.
It is crucial to handle (RS)-2-(4-bromo-2-fluorophenyl)oxirane with care, as it may present health and environmental risks if not properly managed. Precautions should be taken to minimize exposure and ensure the safe use of (RS)-2-(4-bromo-2-fluorophenyl)oxirane in both research and industrial applications.

Upstream product

• 151982-51-3 4-bromo-2-fluorobenzoyl chloride 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1379358-56-1 1-(4-bromo-2-fluorophenyl)-2-chloroethanone 

Downstream Products

• 1400996-94-2 (R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine 
• 1400996-98-6 (R)-N-(3-fluoro-4-(morpholin-2-yl)phenyl)-5-(trifluoromethyl)pyrimidin-2-amine 
• 1400997-78-5 (RS)-[2-(4-bromo-2-fluorophenyl)-2-hydroxyethyl]-(2-hydroxyethyl)carbamic acid tertbutyl ester 
• 1400997-79-6 (RS)-2-(4-bromo-2-fluorophenyl)morpholine-4-carboxylic acid tert-butyl ester 
• 1400997-85-4 (R)-tert-butyl 2-(2-fluoro-4-(5-(trifluoromethyl)pyrimidin-2-ylamino)phenyl)morpholine-4-carboxylate 
• 1400997-84-3 (R)-tert-butyl 2-(4-(5-cyclopropylpyrimidin-2-ylamino)-2-fluorophenyl)morpholine-4-carboxylate 
• 1400997-83-2 (+)-(R)-2-(4-amino-2-fluorophenyl)morpholine-4-carboxylic acid tert-butyl ester 
• 1400997-82-1 (R)-tert-butyl 2-(4-(diphenylmethyleneamino)-2-fluorophenyl)morpholine-4-carboxylate 
• 1400997-81-0 (+)-(R)-tert-butyl 2-(4-bromo-2-fluorophenyl)morpholine-4-carboxylate 
• 1400997-80-9 (-)-(S)-tert-butyl 2-(4-bromo-2-fluorophenyl)morpholine-4-carboxylate 
• 1400997-77-4 (RS)-1-(4-bromo-2-fluorophenyl)-2-(2-hydroxyethylamino)ethanol 

Relevant academic research and scientific papers

HETEROCYCLIC AMINE DERIVATIVES

The present invention relates to compounds of formula (I) wherein R1 is hydrogen, lower alkyl, halogen, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, cyano, nitro, C3-6-cycloalkyl, -CH2-C3-6-cycloalkyl, -O-CH2-C3-6-cycloalkyl, -O-(CH2)2-O-lower alkyl, S(O)2CH3, SF5, -C(O)NH-lower alkyl, phenyl, -O-pyrimidinyl, optionally substituted by lower alkoxy substituted by halogen, or is benzyl, oxetanyl or furanyl; m Ar is aryl or heteroaryl, selected from the group consisting of phenyl, naphthyl, pyrimidinyl, pyridinyl, benzothiazolyl, quinolinyl, quinazolinyl, benzo[d][1.3]dioxolyl, 5,6,7,8- tetrahydro-quinazolinyl, pyrazolyl, pyrazinyl, pyridazinyl, or 1,3,4-oxadiazolyl; Y is a bond, -CH2-, -CH2CH2-, -CH(CF3)- or -CH(CH3)-; R2 is hydrogen or lower alkyl; A is CR or N; and R is hydrogen, cyano, halogen or lower alkyl; R' is hydrogen or halogen; with the proviso that when R' is halogen, then A is CH; B is CH or N; n is 0, 1 or 2; X is a bond, -CH2- or -O-; pharmaceutical active acid addition salts thereof. It has now been found that the compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

HETEROCYCLIC AMINE DERIVATIVES

The present invention relates to compounds of formula I wherein A, B, X, Y, Ar, R1, R2, R′, m and n are as defined herein and to pharmaceutical active acid addition salts thereof. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.