1400998-54-0Relevant articles and documents
4-Isocyanopermethylbutane-1,1,3-triol (IPB): A convertible isonitrile for multicomponent reactions
Neves Filho, Ricardo A.W.,Stark, Sebastian,Morejon, Micjel C.,Westermann, Bernhard,Wessjohann, Ludger A.
, p. 5360 - 5363 (2012/10/30)
The synthesis and applications of 4-isocyanopermethylbutane-1,1,3-triol (IPB) as a new convertible isonitrile (isocyanide) for isocyanide-based multicomponent reactions (IMCRs) like Ugi, Ugi-Smiles, and Passerini reactions are described. The primary products obtained from these IMCRs can be converted into highly activated N-acylpyrroles, which upon treatment with nucleophiles can be transformed into carboxylic acids, esters, amides, alcohols, and olefins. In this sense the reagent can be seen as a neutral carbanion equivalent to formate (HO2C-), and carboxylates or carboxamides etc. (RNu-CO-).