1401008-32-9Relevant academic research and scientific papers
Synthesis of Novel Pyrazole Derivatives as Antineoplastic Agent
Rizk, Sameh A.,El-Sayed, Amira A.,Mounier, Marwa M.
, p. 3358 - 3371 (2017)
Anticancer evaluation of pyrazole 2 and Schiff base 5 is reported. Synthesis of some important heterocyclic compounds via 2,3-diaryloxirane-2,3-dicarbonitrile 1, pyrazole 2, and Schiff base 5 with different nitrogen nucleophiles afforded new routes for synthesized fused heterocyclic derivatives. These compounds can be used as a key starting materials to synthesize some important imidazolo-[4,5-c]pyrazole, pyrazolo[3,4-e]1,2,4-triaging, imidazolo[3,2-b]pyrazole, and pyrazolo-pyrazine, as anticancer reagents showed good results at optimum conditions (400–500?ppm), particularly the bridge head nitrogen compounds, and could be used to improve them. Electromeric effect of the halogen atom in the aryl moieties can be controlled upon the rate of reaction and the yield of the product. The structure of the synthesized new compounds would be characterized by elemental and spectral data.
Direct synthesis of 2,3-diaryloxirane-2,3-dicarbonitriles from aroyl chlorides using potassium hexacyanoferrate(II) as an eco-friendly cyanide source
Li, Zheng,Xu, Jun,Niu, Pengxian,Liu, Chenhui,Yang, Jingya
, p. 8880 - 8883 (2012/10/29)
A direct synthetic method for 2,3-diaryloxirane-2,3-dicarbonitriles from aroyl chlorides using potassium hexacyanoferrate(II) as an eco-friendly cyanide source, triphenylphosphine as a promoter, and triethylamine as a catalyst is described. This protocol has the features of no use of strong toxic cyanating agents, high yield, and simple work-up procedure.
