1401015-13-1

Basic information

• Product Name: 3-(3,4-dichlorobenzyl)-5-(1H-indol-3-yl)methyl-1-(5-phthalimidopentyl)-2-thioxo-4-imidazolidinone
• CAS NO: 1401015-13-1
• Molecular Weight: 619.571
• Mol File: 1401015-13-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3,4-dichlorobenzyl)-5-(1H-indol-3-yl)methyl-1-(5-phthalimidopentyl)-2-thioxo-4-imidazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dichlorobenzyl)-5-(1H-indol-3-yl)methyl-1-(5-phthalimidopentyl)-2-thioxo-4-imidazolidinone(1401015-13-1)
• EPA Substance Registry System: 3-(3,4-dichlorobenzyl)-5-(1H-indol-3-yl)methyl-1-(5-phthalimidopentyl)-2-thioxo-4-imidazolidinone(1401015-13-1)

Safety Data

• Hazardous Substances Data: 1401015-13-1(Hazardous Substances Data)

Upstream product

• 63273-48-3 5-phthalimido-1-pentanol 
• 95691-09-1 5-phthalimido-1-pentanal 
• 18967-42-5 3,4-dichlorobenzyl isothiocyanate 
• 85-44-9 phthalic anhydride 

Downstream Products

• 1352717-15-7 1-(5-aminopentyl)-3-(3,4-dichlorobenzyl)-5-(1H-indol-3-yl)methyl-2-thioxo-4-imidazolidinone 

Relevant articles and documents

Synthesis of 2-thiohydantoins as somatostatin subtype 4 receptor ligands

A series of 2-thiohydantoins were prepared as somatostatin subtype 4 (sst4) ligands. Reaction of a N-substituted-L-tryptophan methyl ester with an isothiocyanate in the presence of triethylamine readily afforded the target compounds. The 2-thiohydantoins were evaluated for binding affinities in cell lines expressing somatostatin receptor subtypes 2A (sst2A) and 4 (sst4). Compared to the thiourea NNC-26-9100 (3), all 2-thiohydantoins demonstrated lower binding affinities at sst4. Incorporation of the thiourea moiety into the more rigid 2-thiohydantoin nucleus leads to a loss of conformational freedom and may prevent optimal interaction with sst4.