1401031-39-7

Basic information

• Product Name: TRV-130
• Synonyms: TRV130 HCl;TRV130 (hydrochloride);[(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine TRV-130;TRV130 HCl (Oliceridine);(9R)-N-[(3-Methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-6-oxaspiro[4.5]decane-9-ethanamine hydrochloride (1:1);(R)-N-((3-Methoxythiophen-2-yl)methyl)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)ethanamin
• CAS NO: 1401031-39-7
• Molecular Formula: C22H31ClN2O2S
• Molecular Weight: 423.01174
• EINECS: -0
• Mol File: 1401031-39-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: TRV-130(CAS DataBase Reference)
• NIST Chemistry Reference: TRV-130(1401031-39-7)
• EPA Substance Registry System: TRV-130(1401031-39-7)

Safety Data

• Hazardous Substances Data: 1401031-39-7(Hazardous Substances Data)

Usage

Description

Oliceridine hydrochloride, also known as TRV-130, is a μ-opioid receptor (MOR) G protein-biased ligand derived from hydrolyzable tannins found in various plant sources. It possesses potent analgesic properties and is known for causing less gastrointestinal dysfunction and respiratory suppression than morphine at equianalgesic doses. Its unique mechanism of action allows for effective pain relief with fewer side effects, making it a promising pharmaceutical candidate for various applications.

Uses

Used in Pharmaceutical Industry:
Oliceridine hydrochloride is used as an analgesic agent for the management of moderate to severe acute pain. It provides potent pain relief by selectively targeting the μ-opioid receptor (MOR) with G protein-biased signaling, resulting in reduced gastrointestinal dysfunction and respiratory suppression compared to traditional opioids like morphine.
Used in Pain Management:
Oliceridine hydrochloride is employed as a pain management agent, particularly for patients experiencing moderate to severe acute pain. Its G protein-biased mechanism of action modulates the MOR signaling pathways, exerting inhibitory effects on pain perception without causing significant side effects commonly associated with traditional opioids.
Used in Research and Development:
Oliceridine hydrochloride serves as a valuable compound in the research and development of novel pain management therapies. Its unique properties and reduced side effect profile make it an attractive candidate for the development of new drugs and drug delivery systems aimed at improving patient outcomes and safety in pain management.