1401061-71-9Relevant academic research and scientific papers
Identification of a key intermediate in the asymmetric Appel process: One pot stereoselective synthesis of P-stereogenic phosphines and phosphine boranes from racemic phosphine oxides
Rajendran, Kamalraj V.,Gilheany, Declan G.
, p. 10040 - 10042 (2012/11/07)
Sequential treatment of racemic phosphine oxides with oxalyl chloride and chiral non-racemic alcohol generates the same ratios of diastereomeric alkoxyphosphonium salts obtained in the corresponding asymmetric Appel process, strongly implicating the intermediate chlorophosphonium salt in the stereoselecting step. Subsequent reduction allows a novel synthesis of enantioenriched P-stereogenic phosphines-phosphine boranes. The Royal Society of Chemistry 2012.
