1401071-22-4

Basic information

• Product Name: 1,5-bis(3-((dimethylamino)methyl)-4-hydroxyphenyl)penta-1,4-dien-3-one
• Synonyms: 1,5-bis(3-((dimethylamino)methyl)-4-hydroxyphenyl)penta-1,4-dien-3-one
• CAS NO: 1401071-22-4
• Molecular Weight: 422.524
• Mol File: 1401071-22-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,5-bis(3-((dimethylamino)methyl)-4-hydroxyphenyl)penta-1,4-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-bis(3-((dimethylamino)methyl)-4-hydroxyphenyl)penta-1,4-dien-3-one(1401071-22-4)
• EPA Substance Registry System: 1,5-bis(3-((dimethylamino)methyl)-4-hydroxyphenyl)penta-1,4-dien-3-one(1401071-22-4)

Safety Data

• Hazardous Substances Data: 1401071-22-4(Hazardous Substances Data)

Upstream product

• 116546-04-4 3-<(dimethylamino)methyl>-4-hydroxybenzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 

Relevant articles and documents

Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl- substituted curcumin derivatives

Eight dimethylaminomethyl-substituted curcumin derivatives were designed and synthesized. The antioxidant test revealed that the synthesized compounds had higher free radical scavenging activity towards both 2,2-diphenyl-1- picrylhydrazyl free radicals (DPPH) (IC50 1.5-29.9 μM) and galvinoxyl radicals (IC50 4.9-41.1 μM) than the lead compound curcumin. Besides, compound 3a could effectively inhibit the Aβ self-aggregation in vitro. Investigated in phosphate-buffered solutions (pH = 7.4) in the presence or absence of 0.1% FBS 3a showed a good stability while curcumin did not. Furthermore, 3a showed a good lipophilicity (log P = 3.48), suggesting a potential ability to penetrate the blood-brain-barrier. The aqueous solubility of the hydrochloride salt of 3a (16.7 mg/mL) has also been significantly improved as compared with curcumin (0.1 mg/mL).