1401094-73-2Relevant academic research and scientific papers
ORGANOGOLD COMPLEXES AND METHODS FOR MAKING THE SAME
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Paragraph 0473-0479, (2014/02/16)
The present invention relates to chiral ligands deriving from α- and β-amino acids, and from metal complexes formed from the same. The ligands are useful with catalytic gold complexes, particularly Au(I) complexes.
Insights into the mechanism for gold catalysis: Behaviour of gold(i) amide complexes in solution
Bobin, Mariusz,Day, Iain J.,Roe, Stephen M.,Viseux, Eddy M. E.
, p. 6592 - 6602 (2013/07/26)
We report the synthesis and activity of new mononuclear and dinuclear gold amide complexes 1-7. The dinuclear complexes 6b and 7 were characterised by single crystal X-ray analysis. We also report solution NMR and freezing point depression experiments to rationalise their behaviour in solution and question the de-ligation process invoked in gold catalysis.
Gold amides as anticancer drugs: Synthesis and activity studies
Newcombe, Sonya,Bobin, Mariusz,Shrikhande, Amruta,Gallop, Chris,Pace, Yannick,Yong, Helen,Gates, Rebecca,Chaudhuri, Shuvashri,Roe, Mark,Hoffmann, Eva,Viseux, Eddy M. E.
supporting information, p. 3255 - 3260 (2013/06/05)
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells. The Royal Society of Chemistry 2013.
ORGANOGOLD COMPLEXES AND METHODS FOR MAKING THE SAME
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Page/Page column 63, (2012/10/18)
The present invention relates to chiral ligands deriving from a- and β-amino acids, and from metal complexes formed from the same. The ligands are useful with catalytic gold complexes, particularly Au(l) complexes.
