1401197-80-5

Basic information

• Product Name: 5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazole-1-carbothioamide
• CAS NO: 1401197-80-5
• Molecular Weight: 317.362
• Mol File: 1401197-80-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazole-1-carbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazole-1-carbothioamide(1401197-80-5)
• EPA Substance Registry System: 5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazole-1-carbothioamide(1401197-80-5)

Safety Data

• Hazardous Substances Data: 1401197-80-5(Hazardous Substances Data)

Upstream product

• 413585-95-2 C₁₅H₁₀F₂O 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 1401197-92-9 N'-(4-hydroxy-3-methoxybenzylidene)-2-(2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)acetohydrazide 
• 1401197-93-0 N'-(3,4-dimethoxybenzylidene)-2-(2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)acetohydrazide 
• 1401197-82-7 2-(2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)acetohydrazide 
• 1401197-83-8 N'-(2,6-difluorobenzylidene)-2-(2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)acetohydrazide 
• 1401197-87-2 N'-(4-bromobenzylidene)-2-(2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)acetohydrazide 
• 1401197-88-3 N'-(3,4,5-trimethoxybenzylidene)-2-(2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)acetohydrazide 
• 1401197-89-4 N'-(4-(dimethylamino)benzylidene)-2-(2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)acetohydrazide 
• 1401197-90-7 N'-(4-methoxybenzylidene)-2-(2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)acetohydrazide 
• 1401197-81-6 ethyl 2-(2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)acetate 
• 1401197-84-9 2-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazol-4(5H)-one 
• 1401197-94-1 5-(2,6-difluorophenyl)-3-phenyl-1-(4-phenyl-4H-1,3-thiazet-2-yl)-4,5-dihydro-1H-pyrazole 
• 1401197-95-2 1-(4-(4-chlorophenyl)-4H-1,3-thiazet-2-yl)-5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole 
• 1401197-96-3 5-(2,6-difluorophenyl)-1-(4-(4-nitrophenyl)-4H-1,3-thiazet-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazole 
• 1401197-97-4 4-(4-(5-(2,6-difluorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)-2H-1,3-thiazet-2-yl)toluene 

Relevant articles and documents

Synthesis and biological evaluation of novel 4,5-dihydropyrazole derivatives as potent anticancer and antimicrobial agents

A focused library of 4,5-dihydropyrazole dervivatives (4, 5, 6, 7a-h, 8, 9a-g, and 10a-g) were synthesized from novel 5-(2,6-difluorophenyl)-3-phenyl-4, 5-dihydropyrazole-1-carbothioamide 4. The synthesized compounds were characterized using elemental analysis and spectral data (IR, mass spectra, 1H and 13C NMR) and evaluated for antimicrobial activity by broth dilution method and in vitro anticancer activity. Among the synthesized compounds 7a, 9c, 9g, and 10d exhibit broad spectrum antimicrobial activity against tested microbial strains. The in vitro cancer results ascertain 7a, 9c, and 10d are most potent molecules in comparison to reference standard cisplatin.