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1401206-75-4

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1401206-75-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1401206-75-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,1,2,0 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1401206-75:
(9*1)+(8*4)+(7*0)+(6*1)+(5*2)+(4*0)+(3*6)+(2*7)+(1*5)=94
94 % 10 = 4
So 1401206-75-4 is a valid CAS Registry Number.

1401206-75-4Relevant academic research and scientific papers

Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus

Lizarzaburu, Mike,Turcotte, Simon,Du, Xiaohui,Duquette, Jason,Fu, Angela,Houze, Jonathan,Li, Leping,Liu, Jinqian,Reagan, Jeff,Yu, Ming,Medina, Julio C.,Murakoshi, Michiko,Oda, Kozo,Okuyama, Ryo,Nara, Futoshi

, p. 5942 - 5947,6 (2020/07/30)

The discovery and initial optimization of a series of phenylalanine based agonists for GPR142 is described. The structure-activity-relationship around the major areas of the molecule was explored to give agonists 90 times more potent than the initial HTS hit in a human GPR142 inositol phosphate accumulation assay. Removal of CYP inhibition by exploration of the pyridine A-ring is also described.

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