1401236-90-5Relevant academic research and scientific papers
Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines
Fujii, Wataru,Toda, Kazuya,Matsumoto, Kiriko,Kawaguchi, Koichiro,Kawahara, Sei-Ichi,Hattori, Yasunao,Fujii, Hiroshi,Makabe, Hidefumi
supporting information, p. 7188 - 7192 (2013/12/04)
Total synthesis of prodelphinidin B1, B2, and B4 has been accomplished. The key step is Lewis acid-mediated equimolar condensations between an epigallocatechin and/or a gallocatechin nucleophile and an epigallocatechin and/or a gallocatechin electrophile. The antitumor effects of synthetic prodelphinidin B1-B4 against human PC-3 prostate cancer cell lines have been investigated. These compounds showed significant antitumor effects. Their activity seemed to be little bit stronger than EGCG and prodelphinidin B3, known antitumor agent.
Unified approach to catechin hetero-oligomers: First total synthesis of trimer EZ-EG-CA isolated from Ziziphus jujuba
Yano, Takahisa,Ohmori, Ken,Takahashi, Haruko,Kusumi, Takenori,Suzuki, Keisuke
supporting information, p. 7685 - 7688 (2013/04/23)
A catechin hetero-trimer isolated from Ziziphus jujuba has been synthesized. Among three constituent monomers, (-)-epiafzelechin and (-)-epigallocatechin were prepared by de novo synthesis. Trimer formation relied on the unified approach to oligomers based on the bromo-capping and the orthogonal activation, reaching the reported structure of the natural product. The Royal Society of Chemistry 2012.
