1401249-35-1Relevant academic research and scientific papers
2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases
Chen, Pinhong,Horton, Lori B.,Mikulski, Rose L.,Deng, Lisheng,Sundriyal, Sandeep,Palzkill, Timothy,Song, Yongcheng
supporting information, p. 6229 - 6232 (2012/10/29)
Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL), especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat to public health. We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors. Structure activity relationship (SAR) and molecular modeling studies were performed and implications for further inhibitor design are discussed.
