1401253-98-2

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 17453-13-3 2-(4-chlorophenyl)-5-o-tolyl-1,3,4-thiadiazole 
• 117342-61-7 2-(4-chlorophenyl)-1,3,4-thiadiazole 
• 95-46-5 2-methylphenyl bromide 

Relevant academic research and scientific papers

Pd/Cu-catalyzed C-H arylation of 1,3,4-thiadiazoles with (hetero)aryl iodides, bromides, and triflates

The direct C-H arylation of 1,3,4-thiadiazoles with a wide range of (hetero)aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl halides. The utility of the developed protocol is demonstrated by a one-pot C-H arylation-Suzuki coupling sequence.