140130-10-5

Basic information

• Product Name: Oxazole, 5-methyl-2-phenyl-4-(2-propynyl)-
• CAS NO: 140130-10-5
• Molecular Formula: C13H11NO
• Molecular Weight: 197.236
• Mol File: 140130-10-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Oxazole, 5-methyl-2-phenyl-4-(2-propynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 5-methyl-2-phenyl-4-(2-propynyl)-(140130-10-5)
• EPA Substance Registry System: Oxazole, 5-methyl-2-phenyl-4-(2-propynyl)-(140130-10-5)

Safety Data

• Hazardous Substances Data: 140130-10-5(Hazardous Substances Data)

Upstream product

• 6813-61-2 2-(benzoylamino)-4-pentynoic acid 
• 501031-13-6 N-[1-acetyl-4-(trimethylsilyl)but-3-ynyl]benzamide 
• 140130-09-2 4-benzoylamino-1-hexyn-5-one 

Downstream Products

• 132646-34-5 2-(5-methyl-2-phenyl-4-oxazolyl)methyl-5-benzofurancarboxaldehyde 
• 501031-07-8 (S)-3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyrrol-1-yl-propionic acid methyl ester 
• 501031-40-9 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-phenylpropionic acid methyl ester 
• 1038923-37-3 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester 
• 501031-88-5 2-biphenyl-4-yl-3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-propionic acid ethyl ester 
• 501030-45-1 2-biphenyl-3-yl-3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-propionic acid methyl ester 
• 1038923-40-8 5-methyl-2-phenyl-4-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-allyl]-oxazole 
• 140130-21-8 (S)-4-Benzyl-3-{(2S,3R)-2-ethoxy-3-hydroxy-3-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-propionyl}-oxazolidin-2-one 
• 140130-22-9 5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran 
• 1027301-79-6 4-[5-(2,2-Bis-benzyloxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole 
• 1027576-13-1 3-{1-(3-Hydroxy-propoxy)-2-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-ethoxy}-propan-1-ol 
• 1025987-85-2 4-[5-(2,2-Dipropoxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole 
• 181931-91-9 2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile 
• 181931-89-5 4-[5-(3,3-Diethoxy-propyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole 

Relevant articles and documents

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies

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The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an α-alkoxy or α-thioether carboxylic acid group. The influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecule, and the stereochemistry have been studied. The most potent compounds have glucose-lowering activity at doses as low as 0.01 mg/kg.

3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents

Certain 3-(phenyl, chroman-2-yl, benzofuran-5-yl, or benzoxazol-5-yl)-2-(hydroxy or mercapto)propionic acid derivatives and analogs are useful as hypoglycemic and hypocholesterolemic agents.