1401322-58-4Relevant academic research and scientific papers
Synthesis of N-substituted-6-alkoxypteridin-4-amine
Duan, Chonggang,Jia, Jiong,Zhu, Rongxiu,Wang, Jianwu
, p. 865 - 872 (2012/10/29)
A novel seven-step methodology for the synthesis of N-substituted-6- alkoxypteridin-4-amine has been developed with the total yields of 35.4-41%. Twenty new compounds were synthesized by heterocyclization of easily prepared 3-amino-6-bromopyrazine-2-carboxamide, subsequent alkoxylation, chlorination, and nucleophilic substitution. Their structures were confirmed by 1H-NMR, 13C-NMR, ESI-MS, and elemental analysis. The structure of N-(3-chloro-4-fluorophenyl)-6-ethoxypteridin-4-amine was further determined by X-ray crystallographic analysis. It was found that different chlorinating reagents gave different products. The possible chlorination mechanism was discussed.
