1401355-05-2Relevant academic research and scientific papers
Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter
Shintani, Ryo,Ito, Tomoaki,Nagamoto, Midori,Otomo, Haruka,Hayashi, Tamio
, p. 9936 - 9938 (2012/10/29)
A palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary stereocenter at the 3-position has been achieved by the reaction of γ-methylidene-δ-valerolactones with alkyl isocyanates. High enantioselectivity has been realized by employing a newly synthesized chiral phosphoramidite ligand. The Royal Society of Chemistry 2012.
